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KMID : 0378119820090010066
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Chungnam Medical Journal
1982 Volume.9 No. 1 p.66 ~ p.70
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Effects of Mitomycin C on the Growth of Liver in the Chick Embryo
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Abstract
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Mitomycin C is well known as antibacterial, antiviral and antitumor by the mechanism of alkylation. The authors intend to analyze the effects of Mitomycin C on the weight of the liver in the chick embryos. On the sixth day of incubation, 8mg and 16mg of Mitomycin C were injected into the chorioalantoic sac of each incubated eggs of two groups. Between the twelfth day and eighteenth day of incubation a daily total of thirty injected egges of each group was broken for weighting the liver weight of chick embryos. The effects of dose and difference of growth time were analyzed by Zimmerman´s growth formula and Huxley´s relative growth formula and determination of significance in the levels of difference was made by analysis of variance.
The results are summarized as follows
1. Mitomycin C suppressed growth of the liver in the chick embryos and growth inhibition
appeared to be much stronger in the group of 16mg dosage than that of 8mg dosage.
2. Growth rate and specific growth rate were observed to be decreased in the liver with incubation day.
3. Growth center of the growth gradient for injected groups to the control groups in the liver were on the twelfth day.
4. Relative growth of injected groups to the control group were positive allometry in both injected group, and 16mg injected group was more remarkable allometry than 8mg injected group.
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